91Ë¿¹ÏÊÓƵ

IPN Student Profile: Amanda McFarlan

I’veÌýbeen fascinatedÌýby behaviourÌýandÌýunderstandingÌýwhy we do the things weÌýdoÌýfromÌýan early age.ÌýThis curiosity, coupled with my affinity for science subjects, led me to pursue undergraduate studies in neuroscience. I enrolled in the fall of 2012 at Carleton University and began taking all the basic science courses –chemistry, biology, math and physics.ÌýHowever, the one subjectÌýthat caught my attention wasÌýaÌýneuroscienceÌýcourse: Introduction to Mental Health and Disease.ÌýIn this class,ÌýI was introduced to the brainÌýand immediately became intrigued by its complexity.ÌýWe learned about the basics ofÌýtheÌýbrain:ÌýtheÌýorganizationÌýof its many structures, and of course,Ìýthe action potential.ÌýWhat I found the most interesting, however,ÌýwereÌýour discussions on mental illnesses and neurological disorders.ÌýI was captivated byÌýwhat happened when things went awry.ÌýIt quickly became clear to me that I was passionate about studying the brain andÌýthat I hadÌýmade the right decisionÌýto pursueÌýstudiesÌýin the field of neuroscience.ÌýÌý

My curiosity for understandingÌýhow theÌýmalfunction of the brain could lead to a number ofÌýdebilitating disordersÌýprompted me toÌývolunteerÌýatÌýthe Royal OttawaÌýMentalÌýHospital to gain experienceÌýworking with patients with mental illnesses. It is through this experience that I developed a trueÌýunderstanding of the importance of providing adequate treatment and support for individualsÌýsuffering from mental illness.ÌýAs a volunteer,ÌýI was fortunate to have many roles which allowed me to interact withÌýpatients. In one of these roles I volunteered as a recreational therapist assistantÌýonÌýtheÌýschizophrenia unit where I organized leisurely activities for patients. I foundÌýmy experience in this volunteer position to be both extremely rewardingÌýandÌýeducational. IÌýwas thrilled that I could provide an entertaining afternoon for the patients on the unit and at theÌýsame time, have the opportunity to receive hands-on learning in areas that had beenÌýcovered in my university courses.ÌýÌý

My role as a mental health volunteer has had a huge impact on my decision to pursue studies at the graduate level.ÌýTheÌýexperiencesÌýI gained through my 2+ years as a volunteerÌýallowed me to discover my true passion for helping individuals suffering fromÌýneurological disorders andÌýmental illness. ThisÌýultimatelyÌýled me toÌýapply forÌýgraduate studiesÌýin the field of neuroscience at 91Ë¿¹ÏÊÓƵ.ÌýÌý

I started my Master’s degree in 91Ë¿¹ÏÊÓƵ’sÌýIPNÌýin the fall of 2016 underÌýthe supervision ofÌýDr.ÌýJesperÌýSjöström. In this lab, I studyÌýepileptogenesisÌý–the gradual process by which the brain developsÌýepilepsy– in rodentsÌýusing state-of-the-art techniques such asÌýoptogeneticsÌýand 2-photon laser microscopy. I have found this research topic to be extremely fascinating and necessary because there are many unknowns in the field of epilepsy pertaining to the development of the disease.ÌýAdditionally, anti-convulsiveÌýdrugs are the primary treatmentÌýfor epilepsy, but these areÌýonly effective inÌý~70% of cases.ÌýFor these reasons, it is critical to continue studying how epilepsy develops in the brain, to advance our understanding of epilepsy and to discover new ways to treat this disorder.ÌýMy goal is to aid in this endeavor by studying theÌýsynaptic plasticity ofÌýinhibitory interneurons in cortical microcircuitsÌýto determine their impact on neocortical seizuresÌýin rodent models of epilepsy.Ìý

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