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Research Areas:

Behavioural Neuroscience | Cognition & Cognitive Neuroscience

Research Summary:

Our research group studies the neurobiology of memory, with a sharp focus on mechanisms involved in memory maintenance and forgetting. We investigate these phenomena from a systems perspective, using a variety of techniques and organisms; for example, we conduct behavioral studies in genetically modified Drosophila melanogaster, manipulate pharmacologically neurons in specific brain areas in rodents, and assess memory in humans using computer-based tasks. In collaborative projects, our group participates in studies exploring dysfunctions of memory processes in conditions such as Fragile X, autism, or Alzheimer’s disease.

Selected References:

Migues PV, Liu L, Archbold GEB, Einarsson EÖ, Wong J, Bonasia K, Ko SH, Wang YT, Hardt O (2016) Blocking Synaptic Removal of GluA2-Containing AMPA Receptors Prevents the Natural Forgetting of Long-Term Memories. The Journal of Neuroscience 36:3481–3494.

Hardt O, Nader K, Wang YT (2014) GluA2-dependent AMPA receptor endocytosis and the decay of early and late long-term potentiation: possible mechanisms for forgetting of short- and long-term memories. Philosophical Transactions of the Royal Society B: Biological Sciences 369:20130141.

Hardt O, Nader K, Nadel L (2013) Decay happens: the role of active forgetting in memory. Trends in Cognitive Sciences 17:111–120.

Nadel L, Hardt O (2011) Update on memory systems and processes. Neuropsychopharmacology 36:251–273.

Migues PV, Hardt O, Wu DC, Gamache K, Sacktor TC, Wang YT, Nader K (2010) PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nature Neuroscience 13:630–634.

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