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Biochemistry

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Biochemistry

Location

Location

  • Department of Biochemistry
  • McIntyre Medical Sciences Building
  • 3655 Promenade Sir-William-Osler
  • Montreal, QC H3G 1Y6
  • Canada

About Biochemistry

About Biochemistry

The Department of Biochemistry offers M.Sc. and Ph.D. programs, which emphasize laboratory research. Our research interests include molecular and cell biology, the regulation of gene and protein expression, signal transduction, protein structure and function, membrane biology, cell death and differentiation, embryonic development, neurobiology, bioinformatics, and many aspects of cancer. Specialized graduate training programs in Chemical Biology, Human Systems Biology (Bioinformatics), Cancer Research/Oncology (), and Structural Biology () are available. Laboratories are located in the new Bellini Life Sciences Building and Goodman Cancer Centre, and the renovated McIntyre Medical Sciences Building, together comprising one of the best-equipped research facilities in Canada. The outstanding quality of our research has been recognized by recent awards including a Gairdner Award, two Killam Prizes, and five Canada Research Chairs.

Funding

Master's students receive a minimum stipend of $20,000 annually; doctoral students receive $22,000. The Department is committed to helping graduate students secure adequate funding for their research. All students are financially supported either by their supervisor or through fellowships or scholarships. Prospective students are urged to make every effort to secure their own funding. Applications may be made for a variety of fellowships administered by the University or by various federal, provincial, or private agencies. For more information on fellowships and awards, see the Graduate and Postdoctoral Studies website, www.mcgill.ca/gps.

Departmental Seminars

Visiting scientists and senior doctoral students present their research findings to the Department at a regular seminar series throughout the academic year. All graduate students are required to attend the regular seminars and additional special lectures, and are encouraged to attend scientific conferences and symposia.

Master of Science (M.Sc.); Biochemistry (Thesis) (45 credits)
The M.Sc. in Biochemistry introduces students to laboratory-based research at an advanced level. The M.Sc. program offers core courses in advanced biochemistry topics, but focuses on laboratory research. The program provides sophisticated training in the technical as well as theoretical aspects of biochemistry, at one of the leading Biochemistry departments in Canada. The M.Sc. program is an excellent preparation for skilled positions in the biomedical sciences, in industry or the public sector, or for superior research in a Ph.D. program.
Master of Science (M.Sc.); Biochemistry (Thesis) — Chemical Biology (47 credits)
The Chemical Biology Thematic Group is engaged in a diverse range of research topics which span structural biology, enzymology, nucleic acid research, signalling pathways, single molecule biophysics, and biophysical chemistry of living tissues. Among the themes which unite the research being performed in this group is trying to learn new chemistry and physics from biological systems. We have projects relating to pharmaceutically relevant enzymes such as those involved in drug metabolism and antibiotic resistance; development of therapeutic agents in the control of inflammation, cancer and viral infections; the chemical biology of NO; quantification of bioenergetic markers of metabolism; self-assembly mechanisms of the HIV-1 virion capsid; liposome microarray systems to address membrane protein dynamics and recognition; studies on reactive oxygen species translocation across the aqueous/lipid membrane interface; RNAi/antisense technologies; dynamic combinatorial chemistry; protein dynamics and function; mechanistic aspects involved in cellular adhesion and transport in membrane and zeolite channels; and cutting-edge microscopes used to examine transport, motility, and reactivity in cells.

The Chemical Biology graduate option is centred on the pursuit of an original research project under the direction of one or more mentors. The program is supported by 91Ë¿¹ÏÊÓƵ and by the Canadian Institutes of Health Research (CIHR) through its Strategic Training Initiatives program.

The program of training incorporates several important features, including a diverse curriculum and programs of seminars, workshops, and discussion groups designed to provide students with a well-rounded exposure to both the chemical and biological aspects of the discipline. The M.Sc. option provides a foundation in the concepts and approaches of Chemical Biology.

Financial support for students in the program is available from a variety of sources, including competitively awarded CIHR-funded Chemical Biology Scholarship awards.

Master of Science (M.Sc.); Biochemistry (Thesis) — Bioinformatics (45 credits)
Bioinformatics research lies at the intersection of biological/medical sciences and mathematics/computer science/engineering. The intention of the Bioinformatics option is to train students to become researchers in this interdisciplinary field. This includes the development of strategies for experimental design, the construction of tools to analyze datasets, the application of modeling techniques, the creation of tools for manipulating Bioinformatics data, the integration of biological databases, and the use of algorithms and statistics.

M.Sc. level – Students successfully completing the Bioinformatics option at the M.Sc. level will be fluent in the concepts, language, approaches, and limitations of the field.

The option consists of a number of interdisciplinary courses and a seminar designed to bring students from many backgrounds together and to provide a thorough overview of research in this field.

Doctor of Philosophy (Ph.D.); Biochemistry
The Ph.D. in Biochemistry trains students in laboratory-based research at the highest level. The Ph.D. program is streamlined to emphasize independent research, and the many areas of biochemistry studied in our Department offer a wide choice of specialties. Students gain in-depth expertise in biochemistry and the biomedical sciences, with the opportunity to carry out research projects at a world-class level and build collaborations with other leading research groups. Graduates of the Ph.D. program are outstandingly prepared for leadership careers in the basic health sciences in industry, the public sector, or academia.
Doctor of Philosophy (Ph.D.); Biochemistry — Chemical Biology
The Chemical Biology Thematic Group is engaged in a diverse range of research topics which span structural biology, enzymology, nucleic acid research, signalling pathways, single molecule biophysics, and biophysical chemistry of living tissues. Among the themes which unite the research being performed in this group is trying to learn new chemistry and physics from biological systems. We have projects relating to pharmaceutically relevant enzymes such as those involved in drug metabolism and antibiotic resistance; development of therapeutic agents in the control of inflammation, cancer and viral infections; the chemical biology of NO; quantification of bioenergetic markers of metabolism; self-assembly mechanisms of the HIV-1 virion capsid; liposome microarray systems to address membrane protein dynamics and recognition; studies on reactive oxygen species translocation across the aqueous/lipid membrane interface; RNAi/antisense technologies; dynamic combinatorial chemistry; protein dynamics and function; mechanistic aspects involved in cellular adhesion and transport in membrane and zeolite channels; and cutting-edge microscopes used to examine transport, motility, and reactivity in cells.

The Chemical Biology graduate option is centred on the pursuit of an original research project under the direction of one or more mentors. The program is supported by 91Ë¿¹ÏÊÓƵ and by the Canadian Institutes of Health Research (CIHR) through its Strategic Training Initiatives program.

The program of training incorporates several important features, including a diverse curriculum and programs of seminars, workshops, and discussion groups designed to provide students with a well-rounded exposure to both the chemical and biological aspects of the discipline. The Ph.D. option provides advanced training in Chemical Biology based on independent research.

Financial support for students in the program is available from a variety of sources, including competitively awarded CIHR-funded Chemical Biology Scholarship awards.

Doctor of Philosophy (Ph.D.); Biochemistry — Bioinformatics
Bioinformatics research lies at the intersection of biological/medical sciences and mathematics/computer science/engineering. The intention of the Bioinformatics option is to train students to become researchers in this interdisciplinary field. This includes the development of strategies for experimental design, the construction of tools to analyze datasets, the application of modeling techniques, the creation of tools for manipulating Bioinformatics data, the integration of biological databases, and the use of algorithms and statistics.

Ph.D. level – Students successfully completing the Bioinformatics option at the Ph.D. level will be fluent in the concepts, language, approaches, and limitations of the field, and have the capability of developing an independent Bioinformatics research program.

The option consists of a number of interdisciplinary courses and a seminar designed to bring students from many backgrounds together and to provide a thorough overview of research in this field.

Programs, Courses and University Regulations—2011-2012 (last updated Aug. 11, 2011) (disclaimer)

Biochemistry Admission Requirements and Application Procedures

Biochemistry Admission Requirements and Application Procedures

Admission Requirements

Admission Requirements

Admission is based on the candidate’s academic record, letters of recommendation, curriculum vitae, and personal statement. A minimum grade point average of 3.2/4.0 (B+) is required. Once a student has submitted all the required documents, the applicant’s file will be reviewed by the Graduate Admission Committee. Files that do not meet the minimum requirement will not be considered. Applicants must also be accepted by a research supervisor who is a Faculty member or Associate member of the Department of Biochemistry. Recommendation for admission will be made once the applicant has secured a supervisor and adequate financial support. Financial support should be in the form of a stipend from the supervisor's research grant or a fellowship held by the student.

Master's Program

Candidates for the M.Sc. degree must hold a B.Sc. degree or its equivalent in Biochemistry or in related disciplines (e.g., biology, chemistry, physiology, microbiology).

Doctoral Program

Candidates who have completed their M.Sc. degree may be admitted directly to the Ph.D. program. Candidates who are admitted to the M.Sc. program and who are interested in the Ph.D. may transfer directly to the Ph.D. program after successfully completing the transfer seminar (BIOC 701) and all course requirements. The M.Sc. thesis requirement is then waived.

International Applicants

Applicants to graduate studies whose mother tongue is not English and who have not completed an undergraduate or graduate degree from a recognized foreign institution where English is the language of instruction or from a recognized Canadian institution (anglophone or francophone), must submit the following:

TOEFL: Minimum score of 600, or 86 on an Internet-based test with each component score of not less than 20.

or

IELTS: Minimum overall band score of 6.5.

International students who have received their degree outside North America should submit the following:

GRE: Subject Test in Biochemistry, Cell and Molecular Biology with a minimum score of 550. (Not required, but strongly recommended.)

Admission Requirements – Chemical Biology Option

As for the regular graduate programs of the Biochemistry Department, acceptance into the Chemical Biology option consists of two steps:
  1. Preliminary approval by the Department's Graduate Admission Committee based on the student's transcript, references, and other documents submitted with the application. The criteria for assessment at this level are the same as for the regular graduate programs of the Department.
  2. Acceptance by a Chemical Biology research director. The director must propose a research project for the student that provides training in the methods and philosophy of Chemical Biology. Project proposals are assessed by the Chemical Biology Program Committee.

Application Procedures

Application Procedures

Applications will be considered upon receipt of:

  1. application form;
  2. curriculum vitae;
  3. application fee ($100);
  4. two official letters of recommendation from professors on letterhead;
  5. two official transcripts;
  6. test results (TOEFL/GRE) if applicable.

All information is to be submitted to the 91Ë¿¹ÏÊÓƵ Officer, Department of Biochemistry. All applicants are encouraged to contact potential research supervisors during or before the application process since supervisor acceptance is required. Information about the research interests of faculty members can be found at www.mcgill.ca/biochemistry/graduates/research-interests and www.mcgill.ca/biochemistry/department/faculty-members/.

91Ë¿¹ÏÊÓƵ’s online application form for graduate program candidates is available at www.mcgill.ca/gradapplicants/apply.

Dates for Guaranteed Consideration

For dates for guaranteed consideration, please consult the following website: www.mcgill.ca/gradapplicants/programs. Then select the appropriate program.

Programs, Courses and University Regulations—2011-2012 (last updated Aug. 11, 2011) (disclaimer)

Biochemistry Faculty

Biochemistry Faculty

Chair
David Y. Thomas
Associate Chair
Kalle Gehring
Emeritus Professors
Rhoda Blostein; B.Sc., M.Sc., Ph.D.(McG.), F.R.S.C.
Peter E. Braun; B.Sc., M.Sc.(Br. Col.), Ph.D.(Calif., Berk.)
Robert E. MacKenzie; B.Sc.(Agr.)(McG.), M.N.S., Ph.D.(C'nell)
Edward A. Meighen; B.Sc.(Alta.), Ph.D.(Calif., Berk.)
Walter E. Mushynski; B.Sc., Ph.D.(McG.)
Theodore L. Sourkes; M.Sc.(McG.), Ph.D.(C'nell), F.R.S.C.
Clifford P. Stanners; B.Sc.(McM.), M.A., Ph.D.(Tor.)

Professors
Nicole Beauchemin; B.Sc., M.Sc., Ph.D.(Montr.) (joint appt. with Oncology and Medicine)
Albert Berghuis; B.Sc., M.Sc.(Rijks Univ. Groningen, The Netherlands), Ph.D.(Br. Col.) (Canada Research Chair in Structural Biology)
Philip E. Branton; B.Sc., M.Sc., Ph.D.(Tor.), F.R.S.C. (Gilman Cheney Professor of Biochemistry)
Kalle Gehring; B.A.(Brown), M.Sc.(Mich.), Ph.D.(Calif., Berk.) (Chercheur National du FRSQ)
Vincent Giguère; B.Sc., Ph.D.(Laval) (joint appt. with Oncology & Medicine)
Philippe Gros; B.Sc., M.Sc.(Montr.), Ph.D.(McG.), F.R.S.C. (James 91Ë¿¹ÏÊÓƵ Professor)
Roderick R. McInnes; B.Sc., M.D.(Dal.), Ph.D.(McG.)
William Muller; B.Sc., Ph.D.(McG.) (Canada Research Chair in Molecular Oncology)
Alain Nepveu; B.Sc., M.Sc.(Montr.), Ph.D.(Sher.) (James 91Ë¿¹ÏÊÓƵ Professor) (joint appt. with Oncology & Medicine)
Morag Park; B.Sc., Ph.D.(Glas.), F.R.S.C. (Diane & Sal Guerrera Chair in Cancer Genetics) (James 91Ë¿¹ÏÊÓƵ Professor) (joint appt. with Oncology & Medicine)
Jerry Pelletier; B.Sc., Ph.D.(McG.) (James 91Ë¿¹ÏÊÓƵ Professor)
Gordon C. Shore; B.Sc.(Guelph), Ph.D.(McG.)
Joseph Shuster; B.Sc.(McG.), Ph.D.(Calif.), M.D.(Alta.)
John R. Silvius; B.Sc., Ph.D.(Alta.)
Nahum Sonenberg; M.Sc., Ph.D.(Weizmann Inst.), F.R.S.C., F.R.S. (James 91Ë¿¹ÏÊÓƵ Professor)
David Y. Thomas; B.Sc.(Brist.), M.Sc., Ph.D.(Univ. College, Lond.), F.R.S.C. (Canada Research Chair in Molecular Genetics)
Michel L. Tremblay; B.Sc., M.Sc.(Sher.), Ph.D.(McM.), F.R.S.C. (Jeanne & Jean-Louis Levesque Chair in Cancer Research)
Maria Zannis-Hadjopoulos; B.Sc., M.Sc., Ph.D.(McG.) (joint appt. with Oncology & Medicine)
Associate Professors
Maxime Bouchard; B.Sc., Ph.D.(Laval) (Canada Research Chair in Developmental Genetics)
Imed Gallouzi; Maitrise, DEA, Ph.D.(Montpellier, France) (Canada Research Chair in Cellular Information Systems)
Arnim Pause; B.Sc., M.Sc.(U. Konstanz, Germ.), Ph.D.(McG.) (Canada Research Chair in Molecular Oncology)
Jason C. Young; B.Sc.(Tor.), Ph.D.(McM.) (Canada Research Chair in Molecular Chaperones)
Assistant Professors
Josée Dostie; B.Sc.(Sher.), Ph.D.(McG.) (CIHR New Investigators Award; Chercheur Boursier du FRSQ)
Thomas Duchaine; B.Sc., Ph.D.(Montr.) (Chercheur Boursier du FRSQ)
Bhushan Nagar; B.Sc., Ph.D.(Tor.) (Canada Research Chair in the Structural Biology of Signal Transduction)
Martin Schmeing; B.Sc.(McG.), Ph.D.(Yale)
Julie St-Pierre; B.Sc., M.Sc.(Laval), Ph.D.(Camb.)
Jose G. Teodoro; B.Sc.(W. Ont.), Ph.D.(McG.) (CIHR New Investigators Award; Chercheur Boursier du FRSQ)
Associate Members
Karine Auclair (Chemistry), Jacques Genest (Dept. of Medicine), Matthias Götte (Micro. & Immunol.), Michael Hallett (91Ë¿¹ÏÊÓƵ Centre for Bioinformatics), Qutayba Hamid (Meakins-Christie Labs), Robert S. Kiss (Dept. of Medicine), Gregory Miller (Pharm. & Therapeutics), Vassilios Papadopoulos (Dept. of Medicine), Janusz Rak (Mtl. Children's Hospital), Reza Salavati (Inst. of Parasitology), Maya Saleh (Dept. of Medicine), Erwin Schurr (Ctr. For Host Resistance, MGH), Charles Scriver (Pediatrics, MCH), Peter Siegel (Dept. of Medicine), Youla S. Tsantrizos (Dept. of Chemistry), Bernard Turcotte (Dept. of Medicine, Goodman Cancer Ctr.), Simon Wing (Dept. of Medicine), Xiang-Jiao Yang (Mol. Oncol., RVH)
Adjunct Professors
Mirek Cygler (NRC/BRI), Jacques Drouin (Clin. Res. Inst.), Anny Fortin (Dafra Pharma Res. & Deve. Bvba), Tarik Möröy (IRCM), Donald Nicholson (Merck Frosst), Maureen O'Connor (NRC/BRI), Enrico Purisima (NRC/BRI), René Roy (PharmaQAM), Alex Therien (Merck Frosst Canada)
Programs, Courses and University Regulations—2011-2012 (last updated Aug. 11, 2011) (disclaimer)

Master of Science (M.Sc.); Biochemistry (Thesis) (45 credits)

Master of Science (M.Sc.); Biochemistry (Thesis) — Chemical Biology (47 credits)

Master of Science (M.Sc.); Biochemistry (Thesis) — Bioinformatics (45 credits)

Doctor of Philosophy (Ph.D.); Biochemistry

For more information, see Doctor of Philosophy (Ph.D.); Biochemistry .

Doctor of Philosophy (Ph.D.); Biochemistry — Chemical Biology

Doctor of Philosophy (Ph.D.); Biochemistry — Bioinformatics

Faculty of Medicine—2011-2012 (last updated Aug. 11, 2011) (disclaimer)
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